Moundsville is a city in Marshall County, West Virginia, along the Ohio River. It is part of the Wheeling, WV-OH Metropolitan Statistical Area. The population was 9,318 at the 2010 census. It is the county seat of Marshall County. The city was named for the nearby ancient Grave Creek Mound, constructed 250 to 100 BC by indigenous people of the Adena culture.Moundsville was settled in 1771 by English colonists Samuel and James Tomlinson. Fostoria Glass Company was headquartered in Moundsville from 1891 to 1986. The retired West Virginia State Penitentiary operated in Moundsville from 1867 to 1995.